Cervical Cancer

Verified discoveries, trials, and approvals for this cancer type. Every story separates evidence strength, regulatory status, and guideline position.

Latest Discoveries

FDA converts tisotumab vedotin’s accelerated approval to full approval for recurrent or metastatic cervical cancer

Evidence stage: High-Certainty EvidenceRegulatory status: FDA Approved
Cancer type
Cervical Cancer
Published
August 13, 2026

In the randomized, open-label, phase 3 innovaTV 301 trial, tisotumab vedotin significantly extended both overall survival (11.5 months versus 9.5 months) and progression-free survival (4.2 months versus 2.9 months), compared…

Primary source cited

Last reviewed

Major Advances

FDA converts tisotumab vedotin’s accelerated approval to full approval for recurrent or metastatic cervical cancer

Evidence stage: High-Certainty EvidenceRegulatory status: FDA Approved
Cancer type
Cervical Cancer
Published
August 13, 2026

In the randomized, open-label, phase 3 innovaTV 301 trial, tisotumab vedotin significantly extended both overall survival (11.5 months versus 9.5 months) and progression-free survival (4.2 months versus 2.9 months), compared…

Primary source cited

Last reviewed

FDA Approvals

Regulatory approval is separate from evidence certainty and from guideline position. Approval applies only to the exact indication stated in each jurisdiction record.

FDA converts tisotumab vedotin’s accelerated approval to full approval for recurrent or metastatic cervical cancer

Regulatory status: FDA ApprovedEvidence stage: High-Certainty Evidence
Cancer type
Cervical Cancer
Population
Adults with recurrent or metastatic cervical cancer who had received one or two prior systemic regimens (including chemotherapy, with or without bevacizumab or an anti-PD-(L)1 agent), randomized to tisotumab vedotin or investigator's choice of chemotherapy.
View approval details
Last reviewed
2026-08-13

Regulatory status by jurisdiction

United States (FDA)

Status
FDA-approved for the exact stated cancer/use
Indication
Adults with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.
Decision date
2024-04-29

Guideline positions

Guideline

Position
Not addressed
Last verified
2026-08-13

Primary evidence supporting this story

Applies to the exact indication stated.

National mortality data show a substantial drop in cervical cancer deaths among HPV-vaccinated women in England

Regulatory status: FDA ApprovedEvidence stage: Later-Stage Human
Cancer type
Cervical Cancer
Population
Women aged 20-29 in England, tracked via national population-based cervical cancer mortality data from 2001 to 2024, spanning cohorts vaccinated and not vaccinated under England's HPV immunisation program (introduced 2008).
View approval details
Last reviewed
2026-08-13

Regulatory status by jurisdiction

United States (FDA)

Status
FDA-approved for the exact stated cancer/use
Indication
Prevention of cervical, vulvar, vaginal, and anal cancers and precancerous/dysplastic lesions caused by specific HPV types (Gardasil 9's original approved indication) -- cited as evidence the underlying vaccine family is licensed and non-investigational, NOT as an FDA review of the England mortality analysis this record reports.
Decision date
2014-12-10
Access notes
Cited for regulatory-status context only -- this record's actual claims are about a separate, later England-specific mortality analysis, not this original US approval.

Guideline positions

Guideline

Position
Not addressed
Last verified
2026-08-13

Primary evidence supporting this story

Applies to the exact indication stated.

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Related resources

Trusted resources: official cancer information

CancerDiscoveries summarizes verified records in its database. Absence of a listing here does not establish that a treatment lacks regulatory authorization or access.