Endometrial (Uterine) Cancer

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Lunresertib plus camonsertib produces durable responses in advanced endometrial and ovarian cancer in early trial data

Evidence stage: Emerging ClinicalRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
August 13, 2026

In the gynecologic expansion cohort of the first-in-human, phase 1 MYTHIC trial, the combination of lunresertib (a PKMYT1 inhibitor) and camonsertib (an ATR inhibitor) produced durable objective responses in heavily…

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Major Advances

Lunresertib plus camonsertib produces durable responses in advanced endometrial and ovarian cancer in early trial data

Evidence stage: Emerging ClinicalRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
August 13, 2026

In the gynecologic expansion cohort of the first-in-human, phase 1 MYTHIC trial, the combination of lunresertib (a PKMYT1 inhibitor) and camonsertib (an ATR inhibitor) produced durable objective responses in heavily…

Primary source cited

Last reviewed

Clinical Trials

Important: Eligibility and enrollment are not guaranteed, and listing here is not a treatment recommendation. Talk to your care team.

Lunresertib plus camonsertib produces durable responses in advanced endometrial and ovarian cancer in early trial data

Regulatory status: InvestigationalEvidence stage: Emerging Clinical
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT04855656
View trial details
Study design
Non-randomized trial
Population
Adults with advanced, heavily pretreated endometrial cancer (n=27 in this cohort), enrolled in the gynecologic expansion cohort of a first-in-human, phase 1 trial. A separate cohort of the SAME trial (n=24) enrolled patients with platinum-resistant ovarian cancer; both cohorts' results are reported together here since they come from the same combination and the same trial, though this record's cancer_type taxonomy tag reflects the endometrial cohort specifically.
Last reviewed
2026-08-13

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-08-13

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

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CancerDiscoveries summarizes verified records in its database. Absence of a listing here does not establish that a treatment lacks regulatory authorization or access.