Endometrial (Uterine) Cancer

Verified discoveries, trials, and approvals for this cancer type. Every story separates evidence strength, regulatory status, and guideline position.

Latest Discoveries

Trial Watch: Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
October 22, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Active Not Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer, Sarcoma
Published
October 20, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Active Not Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Two Part (Phase1b/ Phase3) Trial of Subcutaneous Dostarlimab Plus Carboplatin-Paclitaxel in Participants With Primary Advanced or Recurrent Endometrial Cancer

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
October 20, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Not Yet Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
October 8, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Not Yet Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
September 22, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator’s Choice in Participants With Endometrial Cancer

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
September 9, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
September 1, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Research type: Registered later-phase trialRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
August 21, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Major Advances

Lunresertib plus camonsertib produces durable responses in advanced endometrial and ovarian cancer in early trial data

Research type: Emerging ClinicalRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
August 13, 2026

In the gynecologic expansion cohort of the first-in-human, phase 1 MYTHIC trial, the combination of lunresertib (a PKMYT1 inhibitor) and camonsertib (an ATR inhibitor) produced durable objective responses in heavily…

Primary source cited

Last reviewed

Clinical Trials

Important: Eligibility and enrollment are not guaranteed, and listing here is not a treatment recommendation. Talk to your care team.

Trial Watch: Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)

Regulatory status: InvestigationalResearch type: Registered later-phase trial
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT06486441
Trial phase
Phase 3
View trial details
Study design
Not specified in this summary
Population
Participants age 18 Years and older with Endometrial Cancer who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-10-22

Regulatory status by jurisdiction

Country or region not specified

Status
Investigational
Last verified
2026-10-22

Cancer-type scope for this record is not yet recorded.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

Regulatory status: InvestigationalResearch type: Registered later-phase trial
Cancer type
Endometrial (Uterine) Cancer, Sarcoma
Trial identifier
NCT03914612
Trial phase
Phase 3
View trial details
Study design
Not specified in this summary
Population
Participants age 18 Years and older with Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-10-20

Regulatory status by jurisdiction

Country or region not specified

Status
Investigational
Last verified
2026-10-20

Cancer-type scope for this record is not yet recorded.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: Two Part (Phase1b/ Phase3) Trial of Subcutaneous Dostarlimab Plus Carboplatin-Paclitaxel in Participants With Primary Advanced or Recurrent Endometrial Cancer

Regulatory status: InvestigationalResearch type: Registered later-phase trial
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT07860450
Trial phase
Phase 3
View trial details
Study design
Not specified in this summary
Population
Participants age 18 Years and older with Endometrial Carcinoma, Neoplasms, Endometrial who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-10-20

Regulatory status by jurisdiction

Country or region not specified

Status
Investigational
Last verified
2026-10-20

Cancer-type scope for this record is not yet recorded.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer

Regulatory status: InvestigationalResearch type: Registered later-phase trial
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT07578649
Trial phase
Phase 3
View trial details
Study design
Not specified in this summary
Population
Participants age 18 Years and older with Endometrial Neoplasms, Endometrial Cancer who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-10-08

Regulatory status by jurisdiction

Country or region not specified

Status
Investigational
Last verified
2026-10-08

Cancer-type scope for this record is not yet recorded.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Regulatory status: InvestigationalResearch type: Registered later-phase trial
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT05256225
Trial phase
Phase 3
View trial details
Study design
Not specified in this summary
Population
Participants age 18 Years and older with Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-09-22

Regulatory status by jurisdiction

Country or region not specified

Status
Investigational
Last verified
2026-09-22

Cancer-type scope for this record is not yet recorded.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator’s Choice in Participants With Endometrial Cancer

Regulatory status: InvestigationalResearch type: Registered later-phase trial
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT07166094
Trial phase
Phase 3
View trial details
Study design
Not specified in this summary
Population
Participants age 18 Years and older with Endometrial Cancer, Recurrent or Progressive Endometrial Cancer who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-09-09

Regulatory status by jurisdiction

Country or region not specified

Status
Investigational
Last verified
2026-09-09

Cancer-type scope for this record is not yet recorded.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

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Trusted resources: official cancer information

CancerDiscoveries summarizes verified records in its database. Absence of a listing here does not establish that a treatment lacks regulatory authorization or access.