Endometrial (Uterine) Cancer

Verified discoveries, trials, and approvals for this cancer type. Every story separates evidence strength, regulatory status, and guideline position.

Latest Discoveries

Trial Watch: Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Evidence stage: Later-Stage HumanRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
September 22, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator’s Choice in Participants With Endometrial Cancer

Evidence stage: Later-Stage HumanRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
September 9, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Evidence stage: Later-Stage HumanRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
September 1, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Trial Watch: Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Evidence stage: Later-Stage HumanRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
August 21, 2026

ClinicalTrials.gov confirms that this Phase 3 study is registered and currently listed as Recruiting. This establishes the study's existence and registry-reported design/status, not a treatment benefit.

Primary source cited

Last reviewed

Lunresertib plus camonsertib produces durable responses in advanced endometrial and ovarian cancer in early trial data

Evidence stage: Emerging ClinicalRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
August 13, 2026

In the gynecologic expansion cohort of the first-in-human, phase 1 MYTHIC trial, the combination of lunresertib (a PKMYT1 inhibitor) and camonsertib (an ATR inhibitor) produced durable objective responses in heavily…

Primary source cited

Last reviewed

Major Advances

Lunresertib plus camonsertib produces durable responses in advanced endometrial and ovarian cancer in early trial data

Evidence stage: Emerging ClinicalRegulatory status: Investigational
Cancer type
Endometrial (Uterine) Cancer
Published
August 13, 2026

In the gynecologic expansion cohort of the first-in-human, phase 1 MYTHIC trial, the combination of lunresertib (a PKMYT1 inhibitor) and camonsertib (an ATR inhibitor) produced durable objective responses in heavily…

Primary source cited

Last reviewed

Clinical Trials

Important: Eligibility and enrollment are not guaranteed, and listing here is not a treatment recommendation. Talk to your care team.

Trial Watch: Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Regulatory status: InvestigationalEvidence stage: Later-Stage Human
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT05256225
Trial phase
Phase 3
View trial details
Study design
Other / not applicable
Population
Participants age 18 Years and older with Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-09-22

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-09-22

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator’s Choice in Participants With Endometrial Cancer

Regulatory status: InvestigationalEvidence stage: Later-Stage Human
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT07166094
Trial phase
Phase 3
View trial details
Study design
Other / not applicable
Population
Participants age 18 Years and older with Endometrial Cancer, Recurrent or Progressive Endometrial Cancer who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-09-09

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-09-09

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Regulatory status: InvestigationalEvidence stage: Later-Stage Human
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT06340568
Trial phase
Phase 3
View trial details
Study design
Other / not applicable
Population
Participants age 18 Years and older with Endometrial Cancer who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-09-01

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-09-01

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Trial Watch: Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Regulatory status: InvestigationalEvidence stage: Later-Stage Human
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT07198074
Trial phase
Phase 3
View trial details
Study design
Other / not applicable
Population
Participants age 18 Years and older with Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma who meet the study-specific registry eligibility criteria; sex eligibility: female.
Last reviewed
2026-08-21

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-08-21

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

Lunresertib plus camonsertib produces durable responses in advanced endometrial and ovarian cancer in early trial data

Regulatory status: InvestigationalEvidence stage: Emerging Clinical
Cancer type
Endometrial (Uterine) Cancer
Trial identifier
NCT04855656
View trial details
Study design
Non-randomized trial
Population
Adults with advanced, heavily pretreated endometrial cancer (n=27 in this cohort), enrolled in the gynecologic expansion cohort of a first-in-human, phase 1 trial. A separate cohort of the SAME trial (n=24) enrolled patients with platinum-resistant ovarian cancer; both cohorts' results are reported together here since they come from the same combination and the same trial, though this record's cancer_type taxonomy tag reflects the endometrial cohort specifically.
Last reviewed
2026-08-13

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-08-13

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

Primary evidence supporting this story

Eligibility varies — review trial criteria.

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Trusted resources: official cancer information

CancerDiscoveries summarizes verified records in its database. Absence of a listing here does not establish that a treatment lacks regulatory authorization or access.