In the randomized, phase 3 PANOVA-3 trial, adding Tumor Treating Fields (TTFields) -- a wearable device that emits alternating electric fields through skin-worn arrays -- to standard chemotherapy significantly extended…
In this prospective cohort, plasma KRAS ctDNA positivity correlated with worse survival and higher metastatic progression, while peritoneal KRAS ctDNA positivity correlated with occult/peritoneal metastatic risk — two related but…
The study shows that the personalized vaccine can generate long-lived cancer-specific T-cell responses and that those responses were associated with longer recurrence-free survival in this small Phase I cohort. A…
In the randomized, phase 3 PANOVA-3 trial, adding Tumor Treating Fields (TTFields) -- a wearable device that emits alternating electric fields through skin-worn arrays -- to standard chemotherapy significantly extended…
In this prospective cohort, plasma KRAS ctDNA positivity correlated with worse survival and higher metastatic progression, while peritoneal KRAS ctDNA positivity correlated with occult/peritoneal metastatic risk — two related but…
The study shows that the personalized vaccine can generate long-lived cancer-specific T-cell responses and that those responses were associated with longer recurrence-free survival in this small Phase I cohort. A…
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Last reviewed
FDA Approvals
Regulatory approval is separate from evidence certainty and from guideline position. Approval applies only to the exact indication stated in each jurisdiction record.
Adults with locally advanced pancreatic adenocarcinoma, randomized to Tumor Treating Fields (TTFields) plus gemcitabine/nab-paclitaxel chemotherapy or chemotherapy alone, in the randomized, open-label, phase 3 PANOVA-3 trial.
View approval details
Last reviewed
2026-08-13
Regulatory status by jurisdiction
United States (FDA)
Status
FDA-approved for the exact stated cancer/use
Indication
Adults with locally advanced pancreatic cancer, used concomitantly with gemcitabine and nab-paclitaxel.
Decision date
2026-02-11
Access notes
A DEVICE approval, not a drug approval -- disclosed as such, not conflated with a pharmaceutical regulatory action.
Tumor Treating Fields With Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study (Journal of Clinical Oncology). DOI 10.1200/JCO-25-00746.
In the randomized, phase 3 PANOVA-3 trial, adding Tumor Treating Fields (TTFields) -- a wearable device that emits alternating electric fields through skin-worn arrays -- to standard chemotherapy significantly extended…
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