Cancer research moves fast. We make it understandable.
The study shows that the personalized vaccine can generate long-lived cancer-specific T-cell responses and that those responses were associated with longer recurrence-free survival in this small Phase I cohort. A…
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A specific expanded FDA approval exists for trastuzumab deruxtecan in a defined HR-positive, HER2-low/ultralow metastatic breast cancer population after endocrine therapy, based on a significant progression-free-survival benefit in DESTINY-Breast06.
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In the randomized, placebo-controlled ADRIATIC trial, durvalumab given as consolidation therapy after concurrent chemoradiotherapy meaningfully extended both overall survival and progression-free survival compared with placebo in limited-stage small cell lung…
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PT217 (peluntamig), an investigational bispecific antibody targeting DLL3 and CD47, is being tested in an ongoing, open-label, first-in-human, Phase 1/2 trial (SKYBRIDGE), primarily to establish safety and an appropriate dose…
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In the randomized, double-blind, placebo-controlled INAVO120 trial, adding inavolisib to palbociclib and fulvestrant significantly delayed disease progression compared with palbociclib and fulvestrant alone, in a PIK3CA-mutated, endocrine-resistant, first-line metastatic breast…
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In the randomized, double-blind, placebo-controlled INDIGO trial, vorasidenib significantly delayed disease progression (by blinded independent review) and delayed the time to the next anticancer intervention, compared with placebo, in a…
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Afamitresgene autoleucel is an engineered T-cell therapy — reportedly the first engineered cell therapy approved for a solid tumor in the United States — that received accelerated approval based on…
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