Personalized & Precision Medicine
Personalized and precision medicine tailors cancer treatment based on an individual’s genetic profile, tumor characteristics, and lifestyle factors. This approach enhances treatment effectiveness, minimizes side effects, and improves patient outcomes through targeted therapies and advanced diagnostics.
CRISPR cuts gene from head and neck cancers through direct injection – 50% of tumors eliminated in animal models
Researchers from Tel Aviv University utilized CRISPR to cut a single gene from cancer cells of head and neck tumorsÑand successfully eliminated 50% of the tumors in model animals.
Widely used diabetes drug could fight cancer, study finds
Metformin is widely used to manage type 2 diabetes, but new research suggests it may also help the immune system fight cancer. A study from the University of Helsinki, published in the Journal for ImmunoTherapy of Cancer, has uncovered how metformin can boost immune cells, making them better at recognizing and attacking cancer cells.
New scanner can see ‘previously undetectable’ cancer spread, research suggests
A new scanner which can distinguish tumour material from healthy tissue more accurately than current methods could change the way breast cancer is diagnosed and treated, researchers have said.
Pancreatic cancer RNA vaccine shows durable T cell immunity
Memorial Sloan Kettering Cancer Center researchers have found RNA neoantigen vaccines that generate long-lived, functional CD8+ T cells in patients with pancreatic ductal adenocarcinoma (PDAC), potentially delaying disease recurrence.
Researchers advance non-invasive cancer detection methods
Researchers at Vilnius University have developed an effective approach to liquid biopsy that contributes to the field of non-invasive cancer detection methods, with significant implications for personalized medicine.
Study finds more effective treatment for head and neck cancer
A recent study explored a new way to treat certain patients with head and neck cancer. The researchers tested whether combining radiation therapy with a drug called cetuximab could improve patient outcomes compared to radiation therapy alone.
Tardigrade proteins show promise in cancer care
Patients undergoing radiation therapy experience debilitating side effects because of toxicity arising from radiation-induced DNA strand breaks in normal peritumoral cells.
THON providing hope to families fighting pediatric cancer
STATE COLLEGE, Pa. (WTAJ) — THON’s 46-hour dance marathon provides many families an avenue of hope when it comes to financing their child’s cancer expenses.
How to lower your risk of skin cancer
GRAND RAPIDS, Mich. (WOOD) — Skin cancer is the most common form of cancer worldwide, and an estimated 1 in 5 Americans develop it by age 70, the Skin Cancer Foundation says. Luckily, there are practical ways to lower your risk of getting it.
Antibody therapy shrinks immunotherapy-resistant lung cancer tumors in mice
An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer (NK) cells in an animal model, a study led by UT Southwestern Medical Center researchers shows.
Common painkiller may help prevent cancer from spreading
Most cancer deaths occur because of metastasis, the process where cancer cells spread from the original tumor to other parts of the body.
Accelerating Cancer Treatment with Precision Medicine & NGS
Asia accounts for nearly half of global cancer cases, making it a major health concern. Recognising the promise of precision oncology, governments across the region have initiated efforts to drive advancements in this space. Let’s take a closer look at the progress being made in precision oncology in the Asia Pacific region.
TROPION-Lung12 phase 3 trial initiated evaluating Datroway as part of adjuvant regimen for patients with early-stage NSCLC at high risk of relapse
he first patient has been dosed in the TROPION-Lung12 phase 3 trial evaluating the efficacy and safety of adjuvant Datroway (datopotamab deruxtecan) plus rilvegostomig or rilvegostomig monotherapy versus standard of care in patients with stage 1 adenocarcinoma non-small cell lung cancer (NSCLC) after complete surgical resection who are ctDNA-positive or have other high risk pathological features.
Royal Surrey staff celebrate radiotherapy treatment for 500th rectal cancer patient
The Royal Surrey NHS Foundation Trust celebrates a milestone, having successfully treated its 500th rectal cancer patient with radiotherapy.
In HER2+ colorectal cancer, anti-HER2 therapy may be less toxic alternative
Patients whose metastatic colorectal cancer has progressed following chemotherapy and who lack mutations in the RAS and BRAF genes (RAS/BRAF wild-type) are typically treated with EGFR inhibitors. For those whose tumors also demonstrate HER2 amplification (extra copies of the HER2 gene), this therapy may be less effective.
Study highlights new target and potential therapy for treatment-resistant cancers
University of Kentucky Markey Cancer Center researchers have discovered a promising new way to combat therapy-resistant cancers by targeting a specific protein modification, according to a study published in the International Journal of Biological Sciences.
DNA-Tagged Gold Nanoparticles Enable Advanced Cancer Detection
Researchers have developed DNA-tagged gold nanoparticles that enhance the detection of cancer cells, offering a new avenue for early diagnosis.
Scientists Find Drug Combo Could Help Immune System Fight… : Oncology Times
Scientists have discovered a promising drug combination that could enhance the immune system’s ability to fight cancer.
The clinical application of artificial intelligence in cancer precision treatment – Journal of Translational Medicine
Background Artificial intelligence has made significant contributions to oncology through the availability of high-dimensional datasets and advances in computing and deep learning. Cancer precision medicine aims to optimize therapeutic outcomes and reduce side effects for individual cancer patients. However, a comprehensive review describing the impact of artificial intelligence on cancer precision medicine is lacking. Observations By collecting and integrating large volumes of data and applying it to clinical tasks across various algorithms and models, artificial intelligence plays a significant role in cancer precision medicine. Here, we describe the general principles of artificial intelligence, including machine learning and deep learning. We further summarize the latest developments in artificial intelligence applications in cancer precision medicine. In tumor precision treatment, artificial intelligence plays a crucial role in individualizing both conventional and emerging therapies. In specific fields, including target prediction, targeted drug generation, immunotherapy response prediction, neoantigen prediction, and identification of long non-coding RNA, artificial intelligence offers promising perspectives. Finally, we outline the current challenges and ethical issues in the field. Conclusions Recent clinical studies demonstrate that artificial intelligence is involved in cancer precision medicine and has the potential to benefit cancer healthcare, particularly by optimizing conventional therapies, emerging targeted therapies, and individual immunotherapies. This review aims to provide valuable resources to clinicians and researchers and encourage further investigation in this field.
Phase II Study Explores Chemo-Free Regimen for HER2-Altered … : Oncology Times
A recent Phase II study has explored the potential of a chemotherapy-free regimen for treating certain cancer patients, offering a promising alternative to traditional chemo-based therapies
Scientists uncover how cancer cells hijack T-cells, making it harder for the body to fight back
Research led by the Chiba Cancer Center Research Institute in Japan has discovered a surprising way cancer evades the immune system. It essentially hacks the immune cells, transferring its own faulty mitochondrial DNA (mtDNA) into the T-cells meant to attack it.
Tracking periods could save your life, doctor warns
<span id="docs-internal-guid-81c4d712-7fff-cf68-1169-5eeab0899cbc">One of the most common cancers, particularly in young people, could be overlooked in its early stages</span>
Prostate cancer and AI: The exciting advances that could transform treatment
Exploring how artificial intelligence is revolutionizing prostate cancer treatment, from early detection to personalized therapy plans.
Key enzyme identified as potential target for cancer immunotherapy
Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme—P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary immune cells involved in combating cancer. P4HA1 causes disruptions in energy production within the cells, which leads to weaker immune cells that are less able to fight cancer and form long-lasting anti-cancer immunity, highlighting P4HA1 as a promising target for treating solid tumors.
