In the randomized, double-blind, phase 3 LEAP-012 trial, adding lenvatinib and pembrolizumab to TACE significantly extended progression-free survival compared with TACE alone (14.6 months versus 10.0 months) in patients with…
In the randomized, double-blind, phase 3 LEAP-012 trial, adding lenvatinib and pembrolizumab to TACE significantly extended progression-free survival compared with TACE alone (14.6 months versus 10.0 months) in patients with…
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Last reviewed
Clinical Trials
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Adults with unresectable, non-metastatic, intermediate-stage hepatocellular carcinoma (liver cancer) without extrahepatic spread or vascular invasion, randomized to transarterial chemoembolization (TACE) plus lenvatinib plus pembrolizumab, or TACE plus dual placebo, at 137 sites across 33 countries.
Last reviewed
2026-08-13
Regulatory status by jurisdiction
Unspecified jurisdiction
Status
Investigational
Last verified
2026-08-13
This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.
LEAP-012: transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (The Lancet). DOI 10.1016/S0140-6736(24)02575-3.
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