Liver Cancer

Verified discoveries, trials, and approvals for this cancer type. Every story separates evidence strength, regulatory status, and guideline position.

Latest Discoveries

Adding lenvatinib and pembrolizumab to TACE improves progression-free survival in liver cancer, but the trial’s overall-survival goal was not met

Evidence stage: Later-Stage HumanRegulatory status: Investigational
Cancer type
Liver Cancer
Published
August 13, 2026

In the randomized, double-blind, phase 3 LEAP-012 trial, adding lenvatinib and pembrolizumab to TACE significantly extended progression-free survival compared with TACE alone (14.6 months versus 10.0 months) in patients with…

Primary source cited

Last reviewed

Major Advances

Adding lenvatinib and pembrolizumab to TACE improves progression-free survival in liver cancer, but the trial’s overall-survival goal was not met

Evidence stage: Later-Stage HumanRegulatory status: Investigational
Cancer type
Liver Cancer
Published
August 13, 2026

In the randomized, double-blind, phase 3 LEAP-012 trial, adding lenvatinib and pembrolizumab to TACE significantly extended progression-free survival compared with TACE alone (14.6 months versus 10.0 months) in patients with…

Primary source cited

Last reviewed

Clinical Trials

Important: Eligibility and enrollment are not guaranteed, and listing here is not a treatment recommendation. Talk to your care team.

Adding lenvatinib and pembrolizumab to TACE improves progression-free survival in liver cancer, but the trial’s overall-survival goal was not met

Regulatory status: InvestigationalEvidence stage: Later-Stage Human
Cancer type
Liver Cancer
Trial identifier
10.1016/S0140-6736(24)02575-3
View trial details
Study design
Randomized controlled trial
Population
Adults with unresectable, non-metastatic, intermediate-stage hepatocellular carcinoma (liver cancer) without extrahepatic spread or vascular invasion, randomized to transarterial chemoembolization (TACE) plus lenvatinib plus pembrolizumab, or TACE plus dual placebo, at 137 sites across 33 countries.
Last reviewed
2026-08-13

Regulatory status by jurisdiction

Unspecified jurisdiction

Status
Investigational
Last verified
2026-08-13

This record has no structured cancer-type scope on file yet — editorial review recommended before treating it as applicable to a specific cancer type.

Primary evidence supporting this story

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CancerDiscoveries summarizes verified records in its database. Absence of a listing here does not establish that a treatment lacks regulatory authorization or access.