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FDA approves perioperative pembrolizumab for head and neck cancer — the first approval for this cancer in 6 years

Evidence stage: High-Certainty EvidenceRegulatory status: FDA Approved
Cancer type
Head and Neck Cancer
Published
August 13, 2026

In the randomized, open-label, phase 3 KEYNOTE-689 trial, adding pembrolizumab before and after surgery to standard treatment significantly extended event-free survival in patients with resectable, locally advanced, PD-L1-positive head and…

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