Search and filter stories that passed editorial review. Evidence strength, regulatory status, and guideline position are shown separately and are never inferred from one another.
53 verified discoveries match your filters.
The study identifies GATA6 as an important regulator of colorectal-cancer biology and a potential research target, but it does not establish a GATA6-directed treatment for patients. Researchers found that knocking…
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In the randomized, phase 3 AMBASSADOR trial, adjuvant pembrolizumab after radical surgery significantly extended disease-free survival compared with observation alone in patients with high-risk muscle-invasive or locally advanced urothelial carcinoma.…
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An investigational NSCLC vaccine (BNT116) is being tested in an ongoing, open-label, first-in-human trial (estimated enrollment 320, sponsor BioNTech SE) with multiple treatment cohorts, primarily to establish safety (dose-limiting toxicities,…
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In this prospective cohort, plasma KRAS ctDNA positivity correlated with worse survival and higher metastatic progression, while peritoneal KRAS ctDNA positivity correlated with occult/peritoneal metastatic risk — two related but…
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Across two validation cohorts, an 18-gene urine test (MPS2) substantially outperformed PSA alone (AUC 0.81–0.82 vs. 0.60) for detecting higher-grade prostate cancer, with modeled reductions in unnecessary biopsies, including in…
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In mismatch repair-deficient rectal cancer specifically, dostarlimab produced a high rate of clinical complete response — most of it sustained at 12 months, with 92% two-year recurrence-free survival across the…
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The study shows that the personalized vaccine can generate long-lived cancer-specific T-cell responses and that those responses were associated with longer recurrence-free survival in this small Phase I cohort. A…
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A specific expanded FDA approval exists for trastuzumab deruxtecan in a defined HR-positive, HER2-low/ultralow metastatic breast cancer population after endocrine therapy, based on a significant progression-free-survival benefit in DESTINY-Breast06.
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In the randomized, placebo-controlled ADRIATIC trial, durvalumab given as consolidation therapy after concurrent chemoradiotherapy meaningfully extended both overall survival and progression-free survival compared with placebo in limited-stage small cell lung…
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PT217 (peluntamig), an investigational bispecific antibody targeting DLL3 and CD47, is being tested in an ongoing, open-label, first-in-human, Phase 1/2 trial (SKYBRIDGE), primarily to establish safety and an appropriate dose…
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