A recent comprehensive review suggests that increased coffee consumption, particularly caffeinated coffee, may be associated with a reduced risk of developing endometrial cancer, which originates in the lining of the uterus. The analysis encompassed 24 studies with a combined participant pool of 699,234 individuals, among whom 9,833 cases of endometrial cancer were identified. Findings indicated that individuals with the highest coffee intake exhibited a 29% lower risk of developing this cancer compared to those with the lowest consumption. The protective effect was more pronounced with caffeinated coffee than with decaffeinated varieties.
Researchers propose that coffee’s rich composition of antioxidants and bioactive compounds may contribute to this protective association. These substances could potentially reduce inflammation, regulate hormone levels such as insulin and estrogen, and inhibit the proliferation of cancer cells. While these findings are promising, the study is observational and does not establish a direct causal relationship between coffee consumption and reduced endometrial cancer risk. Further longitudinal research is necessary to determine optimal consumption levels and to understand how factors like age, body weight, hormone therapy, and genetic predispositions may influence this association.
