Recent research has identified the GATA6 protein as a significant factor in colon cancer progression. Overexpression of GATA6 has been linked to tumor growth and metastasis in colon cancer patients. In studies using mouse models, inhibiting GATA6 led to reduced tumor growth and improved survival rates, highlighting its potential as a therapeutic target.
GATA6 functions as a transcription factor, binding to specific DNA regions known as enhancers that are activated in cancer cells, thereby promoting cancer progression. It also interacts with the tumor-suppressor protein CTCF, which regulates genome structure. Targeting GATA6 could disrupt these interactions, offering a promising avenue for developing new treatments for colon cancer. Click for More Details
