A recent study by researchers from MIT, Brigham and Women’s Hospital, and the University of Iowa has explored a novel approach to protect healthy tissues during radiation therapy by leveraging a protein found in tardigrades, microscopic organisms renowned for their resilience to extreme conditions. Tardigrades produce a unique damage suppressor protein (Dsup) that binds to DNA, shielding it from radiation-induced harm. The research team developed a method to deliver messenger RNA (mRNA) encoding Dsup into specific tissues of mice prior to radiation exposure. This temporary expression of Dsup resulted in a 50% reduction in DNA breaks in healthy cells at the injection site, without safeguarding the tumors, thereby preserving the efficacy of the radiation treatment.
This innovative strategy holds promise for mitigating the adverse side effects of radiation therapy in cancer patients, such as painful mouth sores and rectal bleeding, which often lead to treatment interruptions. By selectively protecting normal tissues, this approach could enable patients to better tolerate radiation therapy and complete their treatment regimens more effectively. Furthermore, the transient nature of mRNA ensures that the protective effects are temporary, reducing potential long-term risks. Beyond oncology, this technology may have applications in safeguarding astronauts from cosmic radiation during space missions, highlighting its versatile potential. Click for More Details
