Early Palliative Care Improves EOL Comfort in Colorectal Cancer
Early palliative care reduces invasive interventions and enhances comfort at EOL for CRC patients, according to real-world study results.
Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer – BMC Gastroenterology
Background Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects the normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles and join into the progression of multiple diseases. However, the regulatory impacts and associated molecular mechanisms of AG in CRC progression keep unclear. Methods and results In this study, it was demonstrated that AG weakened CRC cell viability in a concentration- and time-dependent manner. In addition, AG accelerated cell apoptosis by triggering ferroptosis. The cell invasion and EMT process were restrained after AG treatment, but these impacts were reversed after Fer-1 addition. Moreover, it was uncovered that AG retarded Nrf2/HO-1/GPX4 activation. Additionally, AG modulated PTC cell viability and stimulated ferroptosis. At last, it was illustrated that AG suppressed tumor growth in vivo. Conclusion In conclusion, it was disclosed that AG suppressed cell proliferation and EMT process through inducing ferroptosis in CRC, and retarded Nrf2/HO-1/GPX4 activation. This discovery suggested that AG may be one effective drug for ameliorating CRC progression.
In HER2+ colorectal cancer, anti-HER2 therapy may be less toxic alternative
Patients whose metastatic colorectal cancer has progressed following chemotherapy and who lack mutations in the RAS and BRAF genes (RAS/BRAF wild-type) are typically treated with EGFR inhibitors. For those whose tumors also demonstrate HER2 amplification (extra copies of the HER2 gene), this therapy may be less effective.
Medicinal plant has great potential to fight colorectal cancer
Artemisia herba-alba shows promise in combating colorectal cancer, offering new hope through its powerful medicinal properties.
Increased Calcium Intake Linked to Reduced Colorectal Cancer Risk
Munich news, health insurance, technology, jobs and other topics for expatriates. The Eye Newspapers covers daily news and offers services for foreigners.
A new blood test accurately screens for colorectal cancer, researchers say
It could become the second to reach the market, and potentially help boost screening rates.
Bristol Myers’ colorectal cancer drug significantly reduces relapse risk
Clinical trials indicate that Bristol Myers’ new drug effectively lowers the risk of cancer relapse in colorectal patients.
Pfizer announces successful trial results for colorectal cancer drug
Pfizer’s latest clinical trial shows promising results for its new colorectal cancer drug, marking a significant advancement in treatment options.
Amgen Lumakras cleared for colorectal cancer (AMGN:NASDAQ) | Seeking Alpha
Amgen (AMGN) stock in focus as U.S. approval for its lung cancer drug expands for metastatic colorectal cancer. Read more here.
We Spoke To A Colorectal Cancer Doctor Who Shared 5 Things We Should All Stop Doing Immediately
Cases of colorectal cancer have been rapidly increasing among young adults, so we spoke to a doctor to get some helpful tips.
