Treatment Innovations
Innovations in cancer treatment are transforming patient care by introducing more precise, effective, and less invasive therapies. Immunotherapy, including checkpoint inhibitors and CAR-T cell therapy, has revolutionized cancer care by harnessing the immune system to target and destroy cancer cells.
CARsgen’s Claudin18.2 CAR-T Therapy Satri-cel Granted Breakthrough Therapy Designation by the NMPA
SHANGHAI, March 2, 2025 /PRNewswire/ — CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces that the Center for Drug Evaluation (CDE) of China’s National Medical Products Administration (NMPA) has granted Breakthrough Therapy Designation (BTD) to satricabtagene autoleucel (“satri-cel”, CT041) for the treatment of Claudin18.2-positive advanced gastric/gastroesophageal junction cancer (G/GEJ) in patients who have failed at least two prior lines of therapy.
Dr Cruz-Correa on the FDA Approval of Tislelizumab Plus Chemotherapy for Metastatic Gastric/GEJ Cancer
“I think the combination of a longer time of connectivity [between tislelizumab and] the receptor [and] the fact that [this agent] avoids the other macrophages…could have been partly responsible for the efficacy that we saw.”
FDA Grants Breakthrough Status to Endometrial Cancer Assay
The OncoSignature multiplex immunofluorescence assay received breakthrough device designation from the FDA for identifying patients with endometrial cancer who may benefit from ACR-368 (prexasertib) treatment.
Treatment advances across the cervical cancer spectrum – Nature Reviews Clinical Oncology
In this Review, the authors discuss key clinical trials and therapeutic advances that have informed the current treatment landscape for cervical cancers of all stages, including refinement of surgical management approaches, the establishment of chemoradiotherapy, and the integration of anti-angiogenic agents, immune-checkpoint inhibitors and antibody–drug conjugates.
3News exclusive: Breakthrough radiation therapy at University Hospitals cuts treatment time from weeks to days
A revolutionary advancement in cancer treatment at UH Seidman Cancer Center is dramatically reducing the time patients spend receiving radiation therapy.
How to prime tumors to be defeated by cancer immunotherapy
Experts have thought that immune cells had to be inside of tumors for one type of immunotherapy, known as checkpoint inhibitors, to work.
This AI is creating cancer-killing molecules
The hunt for cancer-combatting antibodies normally relies upon human lab scientists combing through vast amounts of data. LabGenius’ automated AI robotic system has disrupted that process.
Cheap diabetes drug taken by millions of Britons could protect against deadly cancer
A diabetes drug which costs just 35p per pill could help prevent an aggressive form of blood cancer, according to University of Cambridge researchers.
Common antiparasitic drug shows promise in halting growth of aggressive skin cancer
A common pinworm medication may stop and reverse cancer growth in Merkel cell carcinoma, an aggressive form of skin cancer, according to research led by University of Arizona Cancer Center researchers
Medical cannabis shows potential to fight cancer, largest-ever study finds
Analysis aims to solidify agreement on cannabis’s potential as a cancer treatment, lead author of research says
Detecting invasive nodules could be key to preventing unnecessary pancreatic cancer surgery
Pancreatic cysts are fluid-filled sacs that can form in the pancreas.
The Targeted Pulse: Discover the FDA’s Holiday Moves For Solid Tumors, Gastric, and GEJ Cancers
The subcutaneous formulation of nivolumab (Opdivo Qvantig) received FDA approval for all previously approved adult solid tumor indications as monotherapy, maintenance therapy, or in combination with chemotherapy or cabozantinib (Cabometyx). Data from the phase 3 CheckMate-67T study (NCT04810078) provided support for this approval. In the trial, subcutaneous nivolumab was compared with its intravenous formulation.
China’s National Medical Products Administration (NMPA) Approves VYLOY™ (zolbetuximab) for First-Line Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
OKYO, Jan. 5, 2025 /PRNewswire/ — Astellas Pharma Inc. (TSE:4503, President and CEO: Naoki Okamura, “Astellas”) today announced that China’s National Medical Products Administration (NMPA) has approved VYLOY™ (zolbetuximab), in combination with fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of patients with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors are claudin (CLDN) 18.2 positive.
How a common diabetes drug may help the immune system fight cancer
Metformin is best known as a reliable and affordable medication for managing type 2 diabetes.
Unique Stanford Medicine-designed AI predicts cancer prognoses, responses to treatment
A new artificial intelligence tool developed at Stanford Medicine combines data from medical images with text to predict cancer prognoses and treatment responses.
Huge breakthrough as breast cancer pill approved for NHS
A “huge breakthrough” in breast cancer treatment has arrived with the NHS approval of a twice-daily pill for the most common form of advanced disease.
Deadliest Catch Star Captain “Wild” Bill Wichrowski’s Cancer Journey Is an Inspiring Tale
Despite being a season apart, Captain “Wild” Bill Wichrowski was forced to leave the Season 20 crabbing season early for cancer treatment.
Key mechanism behind prostate cancer drug resistance reveals potential new treatment strategy
A team of University of Kentucky Markey Cancer Center researchers has found the mechanism that grants prostate cancer resistance to enzalutamide, a frequently used drug.
A new approach to cancer treatment: Tiny vesicles help the immune system fight tumors
Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University and colleagues have developed a promising new approach to cancer treatment.
A new drug delivery system may help patients with a rare eye cancer
A multi-institutional study led by Moffitt Cancer Center found that percutaneous hepatic perfusion using a melphalan hepatic delivery system may help patients with a rare eye cancer that has spread to their liver.
Breast cancer pill ‘step in the right direction’
Two women who had breast cancer say a new pill which helps reduce its spread is a “step in the right direction”.
Scientists discover lung cancer weakness that could prevent relapse
Scientists have discovered a new weakness in lung cancer that could lead to better treatments and help prevent the disease from coming back.
Revolutionary DNA Method Could Save Thousands from Ineffective Cancer Treatments
Cambridge researchers developed a new DNA classification system that reveals hidden patterns in cancer, potentially transforming how doctors identify patients who will respond to immunotherapy treatments.
Patients with advanced skin cancer to test a new vaccine in NHS drive
Patients with advanced skin cancer will be able to test a new vaccine as part of a drive to speed up the development of new treatments.
